MatriXpecâ„¢
Hydrogels
MatriXpecâ„¢ hydrogels are developed to offer tissue-specific microenvironments for 3D cell culture. MatriXpecâ„¢ hydrogels allow running experiments in truly representative substrates that mimic the biological clues of the native extracellular matrix. Besides the conventional MatriXpecâ„¢, we also offer MatriXpecâ„¢ GelMA hydrogels, which is blended with gelatin methacrylate (GelMA) to allow UV photocrosslinking, offering an optimal combination of biochemical and biomechanical properties for bioprinting 3D constructs based on tissue-specific microenvironments.
Why MatriXpecâ„¢ Hydrogels?
TISSUE-SPECIFIC MICROENVIRONMENTS
Each version of MatriXpecâ„¢ - currently available for 15 different tissues - contains hundreds of tissue-specific extracellular matrix proteins derived from the native tissue. It means all and only the ECM proteins of each tissue will be present, leading to a unique combination found only in the tissue microenvironment itself.
DIRECTS CELL BEHAVIOUR AND DIFFERENTIATION
Due to the very particular composition of each version of MatriXpecâ„¢, it is possible to use our hydrogels to direct cell behavior and differentiation. The combination of tissue-specific proteins and biomechanical properties produce clues that cells interpret and react to, ultimately modulating their ability to proliferate, migrate and differentiate.
SUPPORTS 3D VASCULAR NETWORK FORMATION
MatriXpecâ„¢ hydrogels allow the formation of three-dimensional vascular networks when mixed with endothelial cells. This possibility paves the way for larger, clinically relevant, biofabricated tissues.
