MatriXpec™ hydrogels are developed to offer tissue-specific microenvironments for 3D cell culture. MatriXpec™ hydrogels allow running experiments in truly representative substrates that mimic the biological clues of the native extracellular matrix. Besides the conventional MatriXpec™, we also offer MatriXpec™ GelMA hydrogels, which is blended with gelatin methacrylate (GelMA) to allow UV photocrosslinking, offering an optimal combination of biochemical and biomechanical properties for bioprinting 3D constructs based on tissue-specific microenvironments.
MatriXpec™ and MatriXpec™ GelMA are currently available for the following tissues:
Adipose, Bone, Brain, Cartilage, Colon, Kidney, Liver, Lung, Muscle, Myocardium, Pancreas, Skin, Spleen, Stomach, and Vascular.
Why MatriXpec™ Hydrogels?
Each version of MatriXpec™ - currently available for 15 different tissues - contains hundreds of tissue-specific extracellular matrix proteins derived from the native tissue. It means all and only the ECM proteins of each tissue will be present, leading to a unique combination found only in the tissue microenvironment itself.
DIRECTS CELL BEHAVIOUR AND DIFFERENTIATION
Due to the very particular composition of each version of MatriXpec™, it is possible to use our hydrogels to direct cell behavior and differentiation. The combination of tissue-specific proteins and biomechanical properties produce clues that cells interpret and react to, ultimately modulating their ability to proliferate, migrate and differentiate.
SUPPORTS 3D VASCULAR NETWORK FORMATION
MatriXpec™ hydrogels allow the formation of three-dimensional vascular networks when mixed with endothelial cells. This possibility paves the way for larger, clinically relevant, biofabricated tissues.
How does it work?
In addition to our proprietary technologies, TissueLabs also offers a series of consumables, including alginate and alginate-based bioinks; GelMA and GelMA-based bioinks; needles, nozzles, and adapters for hydrogel extrusion.